Issue 35, 2014

In situ self-assembly of peptides in glucan particles for macrophage-targeted oral delivery

Abstract

In this study, an orally administered macrophage-targeting peptide delivery system was constructed through in situ self-assembly of Q11 peptide inside hollow glucan particles (GPs), which are approved by the FDA. The glucan shell efficiently protected the encapsulated peptide from enzymatic degradation in the gastrointestinal tract. β-1,3-(D)-Glucan is recognized by the membrane receptor dectin-1, which is highly expressed by intestinal antigen-presenting cells, including macrophages. GPs are thus efficiently phagocytized by intestinal macrophages. This study is applicable to the pharmaceutical industry for the development of orally delivered macrophage-targeting systems for effective and personalized remedies like immunotherapeutic vaccines.

Graphical abstract: In situ self-assembly of peptides in glucan particles for macrophage-targeted oral delivery

Supplementary files

Article information

Article type
Paper
Submitted
21 Apr 2014
Accepted
30 Jun 2014
First published
09 Jul 2014

J. Mater. Chem. B, 2014,2, 5882-5890

In situ self-assembly of peptides in glucan particles for macrophage-targeted oral delivery

X. Zhang, Y. Zhao, Y. Xu, Y. Pan, F. Chen, A. Kumar, G. Zou and X. Liang, J. Mater. Chem. B, 2014, 2, 5882 DOI: 10.1039/C4TB00626G

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