Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 27, 2014
Previous Article Next Article

Tailoring the material properties of gelatin hydrogels by high energy electron irradiation

Author affiliations

Abstract

Natural hydrogels such as gelatin are highly desirable biomaterials for application in drug delivery, biosensors, bioactuators and extracellular matrix components due to strong biocompatibility and biodegradability. Typically, chemical crosslinkers are used to optimize material properties, often introducing toxic byproducts into the material. In this present work, electron irradiation is employed as a reagent-free crosslinking technique to precisely tailor the viscoelasticity, swelling behavior, thermal stability and structure of gelatin. With increasing electron dose, changes in swelling behavior and rheology indicate increasing amounts of random coils and dangling ends as opposed to helical content, a result confirmed through Fourier transform infrared spectroscopy. Gel fraction, rheology and swelling measurements at 37 °C were used to verify thermal stability in biological conditions. Scanning electron microscopy images of dried gelatin samples support these conclusions by revealing a loss of free volume and apparent order in the fracture patterns. The degree of crosslinking and mesh size are quantified by rubber elasticity theory and the Flory–Rehner equation. Overall, precise control of material properties is demonstrated through the interplay of concentration and irradiation dose, while providing an extensive parameter–property database suitable for optimized synthesis.

Graphical abstract: Tailoring the material properties of gelatin hydrogels by high energy electron irradiation

Back to tab navigation

Supplementary files

Article information


Submitted
17 Mar 2014
Accepted
15 May 2014
First published
06 Jun 2014

J. Mater. Chem. B, 2014,2, 4297-4309
Article type
Paper

Tailoring the material properties of gelatin hydrogels by high energy electron irradiation

E. I. Wisotzki, M. Hennes, C. Schuldt, F. Engert, W. Knolle, U. Decker, J. A. Käs, M. Zink and S. G. Mayr, J. Mater. Chem. B, 2014, 2, 4297
DOI: 10.1039/C4TB00429A

Social activity

Search articles by author

Spotlight

Advertisements