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Issue 26, 2014
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Dendrimers for drug delivery

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Abstract

Due to their nanometric size, dendrimers have been considered as potentially suitable as new vehicles for drug delivery since their infancy. The association of a dendrimer and a drug may occur in different ways, either through covalent or non-covalent interactions. A non-covalent interaction can be the simple encapsulation inside dendrimers that enhances the solubility of lipophilic drugs in water, or electrostatic interactions between the surface and charged drugs (or DNA, RNA, or siRNA). The covalent association may occur through stable bonds, in particular for dendrimers that are considered as active per se, or through cleavable bonds that should be cleaved only when reaching the target (often cancerous cells). In addition, the full structure of the dendrimer can be disassembled under the influence of a trigger such as pH variations. This review will present these strategies and their consequences for drug delivery.

Graphical abstract: Dendrimers for drug delivery

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Publication details

The article was received on 31 Jan 2014, accepted on 24 Apr 2014 and first published on 28 Apr 2014


Article type: Feature Article
DOI: 10.1039/C4TB00171K
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Citation: J. Mater. Chem. B, 2014,2, 4055-4066
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    Dendrimers for drug delivery

    A. Caminade and C. Turrin, J. Mater. Chem. B, 2014, 2, 4055
    DOI: 10.1039/C4TB00171K

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