Tunable thermosensitive behavior of multiple responsive chitin

Abstract

Chitin can be dissolved and homogeneously functionalized in NaOH/urea aqueous solvent. Previously, we reported that chitin modified with acrylamide (AMC) possesses high water solubility and can undergo a sol–gel transition responding to pH and cationic ions. In this report, we further explored the thermosensitive behavior of this multiple responsive chitin. We showed that the sol–gel transition temperature of AMC can be facilely adjusted by the degree of substitution (DS), pH, polymer concentration and the presence of anions or cations. Importantly, AMC can form a hydrogel at 37 °C and return to solution at 4 °C by adjusting experimental parameters. We anticipate this multiple responsive chitin may have potential applications in injectable materials and smart drug delivery.