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Issue 17, 2014

A modular approach to easily processable supramolecular bilayered scaffolds with tailorable properties

Author affiliations

Abstract

Engineering of anisotropic tissues demands extracellular matrix (ECM) mimicking scaffolds with an asymmetric distribution of functionalities. We here describe a convenient, modular approach based on supramolecular building blocks to form electrospun bilayered scaffolds with tailorable properties. Polymers and peptides functionalized with hydrogen-bonding ureido-pyrimidinone (UPy) moieties can easily be mixed-and-matched to explore new material combinations with optimal properties. These combinatorial supramolecular biomaterials, processed by electrospinning, enable the formation of modular fibrous scaffolds. We demonstrate how UPy-functionalized polymers based on polycaprolactone and poly(ethylene glycol) enable us to unite both cell-adhesive and non-cell adhesive characters into a single electrospun bilayered scaffold. We furthermore show that the non-cell adhesive layer can be bioactivated and made adhesive for kidney epithelial cells by the incorporation of 4 mol% of UPy-modified Arg-Gly-Asp (RGD) peptide in the electrospinning solution. These findings show that the UPy-based supramolecular biomaterial system offers a versatile toolbox to form modular multilayered scaffolds for tissue engineering and regenerative medicine applications such as the formation of membranes for a living bioartificial kidney.

Graphical abstract: A modular approach to easily processable supramolecular bilayered scaffolds with tailorable properties

Supplementary files

Article information


Submitted
28 Oct 2013
Accepted
04 Feb 2014
First published
04 Feb 2014

This article is Open Access

J. Mater. Chem. B, 2014,2, 2483-2493
Article type
Paper

A modular approach to easily processable supramolecular bilayered scaffolds with tailorable properties

B. B. Mollet, M. Comellas-Aragonès, A. J. H. Spiering, S. H. M. Söntjens, E. W. Meijer and P. Y. W. Dankers, J. Mater. Chem. B, 2014, 2, 2483 DOI: 10.1039/C3TB21516D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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