Issue 6, 2014

Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin

Abstract

We report a pH-controlled insulin release system to provide an oral administration route. Mesoporous silica was chosen as a drug carrier, and pH-sensitive polymers were coated onto spherical mesocellular foam with pre-adsorbed insulin. We evaluated the insulin release in both acidic and neutral solutions to compare how this system behaves under different pH conditions.

Graphical abstract: Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin

Supplementary files

Article information

Article type
Communication
Submitted
23 Oct 2013
Accepted
28 Nov 2013
First published
02 Dec 2013

J. Mater. Chem. B, 2014,2, 616-619

Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin

S. R. Choi, D. Jang, S. Kim, S. An, J. Lee, E. Oh and J. Kim, J. Mater. Chem. B, 2014, 2, 616 DOI: 10.1039/C3TB21494J

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