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Issue 4, 2014
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Consecutive dynamic resolutions of phosphine oxides

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A crystallization-induced asymmetric transformation (CIAT) involving a radical-mediated racemization provides access to enantiopure secondary phosphine oxides. A consecutive CIAT is used to prepare enantio- and diastereo-pure tert-butyl(hydroxyalkyl)phenylphosphine oxides.

Graphical abstract: Consecutive dynamic resolutions of phosphine oxides

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The article was received on 21 Oct 2013, accepted on 26 Nov 2013 and first published on 27 Nov 2013

Article type: Edge Article
DOI: 10.1039/C3SC52913D
Citation: Chem. Sci., 2014,5, 1322-1327

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    Consecutive dynamic resolutions of phosphine oxides

    F. A. Kortmann, M. Chang, E. Otten, E. P. A. Couzijn, M. Lutz and A. J. Minnaard, Chem. Sci., 2014, 5, 1322
    DOI: 10.1039/C3SC52913D

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