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Issue 86, 2014
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Highly enantioselective tandem enzyme–organocatalyst crossed aldol reactions with acetaldehyde in deep-eutectic-solvents

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Abstract

Deep-eutectic-solvents (DES), e.g. choline chloride and glycerol, have emerged as promising bio-based and cost-effective reaction media. Herein, the first concept of tandem catalysis of enzymes and organocatalysts in such environmentally-friendly DES is reported, focusing on enzymatic in situ acetaldehyde production combined with highly enantioselective crossed aldehyde–aldehyde C–C bond formation organocatalysis. This leads to an integrative concept with straightforward product recovery and promising catalyst recycling, enabling the synthesis of highly valuable optically active building blocks under mild reaction conditions.

Graphical abstract: Highly enantioselective tandem enzyme–organocatalyst crossed aldol reactions with acetaldehyde in deep-eutectic-solvents

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Article information


Submitted
26 Aug 2014
Accepted
12 Sep 2014
First published
16 Sep 2014

RSC Adv., 2014,4, 46097-46101
Article type
Communication

Highly enantioselective tandem enzyme–organocatalyst crossed aldol reactions with acetaldehyde in deep-eutectic-solvents

C. R. Müller, I. Meiners and P. Domínguez de María, RSC Adv., 2014, 4, 46097
DOI: 10.1039/C4RA09307K

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