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Issue 40, 2014
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Implications of surface passivation on physicochemical and bioimaging properties of carbon dots

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Abstract

The prevalence of surface functionalized carbon dots (CDs) with intriguing fluorescence properties has given a new dimension to the field of bioimaging and is perceived as a promising alternative to quantum dots (QDs). In the present work, polyethylene glycol (PEG) and polyethyleneimine (PEI) passivated CDs have been synthesized by one-step hydrothermal carbonization of chitosan. We have made a comparative analysis of the physicochemical and bioimaging properties of PEI based carbon dots (CD-PEI) and PEG based carbon dots (CD-PEG). This article further provides an insight into the role of surface functionality in controlling the bioimaging efficiencies of CDs. The concentration dependent cytotoxic effects of CD-PEI and CD-PEG were studied on normal (BHK-21) and cancer (A549) cell lines and we explored the competitive performance of CD-PEI compared to CD-PEG for bio-applications.

Graphical abstract: Implications of surface passivation on physicochemical and bioimaging properties of carbon dots

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Publication details

The article was received on 08 Mar 2014, accepted on 25 Apr 2014 and first published on 25 Apr 2014


Article type: Paper
DOI: 10.1039/C4RA02017K
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RSC Adv., 2014,4, 20915-20921

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    Implications of surface passivation on physicochemical and bioimaging properties of carbon dots

    A. Sachdev, I. Matai and P. Gopinath, RSC Adv., 2014, 4, 20915
    DOI: 10.1039/C4RA02017K

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