Jump to main content
Jump to site search

Issue 35, 2014
Previous Article Next Article

Epigenetic manipulation of a filamentous fungus by the proteasome-inhibitor bortezomib induces the production of an additional secondary metabolite

Author affiliations

Abstract

The use of epigenetic modifiers, such as histone deacetylase inhibitors and DNA methyltransferase inhibitors, has been explored increasingly as a technique to induce the production of additional microbial secondary metabolites. The application of such molecules to microbial cultures has been shown to upregulate otherwise suppressed genes, and in several cases has led to the production of new molecular structures. In this study, the proteasome inhibitor bortezomib was used to induce the production of an additional metabolite from a filamentous fungus (Pleosporales). The induced metabolite was previously isolated from a plant, but the configuration was not assigned until now; in addition, an analogue was isolated from a degraded sample, yielding a new compound. Proteasome inhibitors have not previously been used in this application and offer an additional tool for microbial genome mining.

Graphical abstract: Epigenetic manipulation of a filamentous fungus by the proteasome-inhibitor bortezomib induces the production of an additional secondary metabolite

Back to tab navigation

Supplementary files

Article information


Submitted
10 Jan 2014
Accepted
31 Mar 2014
First published
17 Apr 2014

RSC Adv., 2014,4, 18329-18335
Article type
Paper

Epigenetic manipulation of a filamentous fungus by the proteasome-inhibitor bortezomib induces the production of an additional secondary metabolite

K. M. VanderMolen, B. A. Darveaux, W. Chen, S. M. Swanson, C. J. Pearce and N. H. Oberlies, RSC Adv., 2014, 4, 18329
DOI: 10.1039/C4RA00274A

Social activity

Search articles by author

Spotlight

Advertisements