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Issue 22, 2014
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A highly efficient and green cascade synthesis of 3-methyl-substituted-4-hydroxy-1-methyl-quinolin-2(1H)-ones under solvent- and catalyst-free conditions

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Abstract

An expeditious and green protocol for the synthesis of 3,3′-methanediylbis(4-hydroxy-1-methylquinolin-2(1H)-one) (MDBHQ) derivatives and 3-((2-amino-6-oxocyclohex-1-enyl)methyl)-4-hydroxy-1-methylquinolin-2(1H)-one (AOCHQ) derivatives has been developed via a cascade Knoevenagel–Michael reaction. The products were obtained in high yield under neat reaction conditions without any work-up or chromatographic purification. The generality and functional tolerance of this environmentally benign protocol is demonstrated.

Graphical abstract: A highly efficient and green cascade synthesis of 3-methyl-substituted-4-hydroxy-1-methyl-quinolin-2(1H)-ones under solvent- and catalyst-free conditions

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Publication details

The article was received on 18 Sep 2013, accepted on 20 Dec 2013 and first published on 20 Dec 2013


Article type: Paper
DOI: 10.1039/C3RA45208E
Citation: RSC Adv., 2014,4, 11300-11304
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    A highly efficient and green cascade synthesis of 3-methyl-substituted-4-hydroxy-1-methyl-quinolin-2(1H)-ones under solvent- and catalyst-free conditions

    S. I. Bhat and D. R. Trivedi, RSC Adv., 2014, 4, 11300
    DOI: 10.1039/C3RA45208E

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