Issue 104, 2014
From the journal:

RSC Advances

Mild and highly efficient metal-free oxidative α-cyanation of N-acyl/sulfonyl tetrahydroisoquinolines†

Changcun Yan,a   Yuxiu Liua  and  Qingmin Wang*a  

* Corresponding authors

a State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin, People's Republic of China
E-mail: wangqm@nankai.edu.cn, wang98@263.net

Abstract

A highly efficient metal-free oxidative α-cyanation reaction of N-acyl/sulfonyl tetrahydroisoquinolines under mild conditions was developed. The reaction uses 2,2,6,6-tetramethylpiperidine N-oxide fluoroborate salt (T+BF4−) as the oxidant and trimethylsilyl cyanide as the source of the cyano group.

Graphical abstract: Mild and highly efficient metal-free oxidative α-cyanation of N-acyl/sulfonyl tetrahydroisoquinolines

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Article information

DOI
https://doi.org/10.1039/C4RA12922A
Article type
Communication
Submitted
17 Sep 2014
Accepted
05 Nov 2014
First published
05 Nov 2014

RSC Adv., 2014,4, 60075-60078

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Mild and highly efficient metal-free oxidative α-cyanation of N-acyl/sulfonyl tetrahydroisoquinolines

C. Yan, Y. Liu and Q. Wang, RSC Adv., 2014, 4, 60075 DOI: 10.1039/C4RA12922A

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