Metal-free radical cascade dichloromethylation of activated alkenes using CH2Cl2: highly selective activation of the C–H bond

Yunfei Tian; Zhong-Quan Liu

doi:10.1039/C4RA12032A

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Metal-free radical cascade dichloromethylation of activated alkenes using CH₂Cl₂: highly selective activation of the C–H bond†

Yunfei Tian^a and Zhong-Quan Liu*^a

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* Corresponding authors

^a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu, P. R. China
E-mail: liuzhq@lzu.edu.cn
Fax: +86 931 8915557
Tel: +86 931 8912500

Abstract

A dicumyl peroxide-initiated highly selective activation of the (sp³)C–H bond in dichloromethane (DCM, CH₂Cl₂) has been achieved, which allows efficient access to dichloronated oxindoles via a free-radical cascade process.

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Article information

DOI: https://doi.org/10.1039/C4RA12032A
Article type: Communication
Submitted: 09 Oct 2014
Accepted: 19 Nov 2014
First published: 19 Nov 2014

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RSC Adv., 2014,4, 64855-64859

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Metal-free radical cascade dichloromethylation of activated alkenes using CH₂Cl₂: highly selective activation of the C–H bond

Y. Tian and Z. Liu, RSC Adv., 2014, 4, 64855 DOI: 10.1039/C4RA12032A

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