Issue 92, 2014
From the journal:

RSC Advances

Renal-specific delivery of prednisolone-folate conjugates for renal ischemia/reperfusion injury†

Qin Zhang,‡a   Yao Fu,‡a   Renhe Liu,b   Tao Gong,a   Xun Suna  and  Zhi-Rong Zhang*a  

* Corresponding authors

a Key Laboratory of Drug Targeting & Drug Delivery Systems Ministry of Education, West China School of Pharmacy Sichuan University, No. 17, Section 3, Renmin Nan Rd, Chengdu, China
E-mail: zrzzl@vip.sina.com

b Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA

Abstract

Prednisolone-folate conjugate (PFC) was synthesized to achieve renal-targeted delivery and specific intracellular release of prednisolone. Our results highlight the significance of folate-mediated targeted delivery to the kidney and the consequent in vivo therapeutic efficacy of PFC against renal ischemia/reperfusion injury.

Graphical abstract: Renal-specific delivery of prednisolone-folate conjugates for renal ischemia/reperfusion injury

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Article information

DOI
https://doi.org/10.1039/C4RA11160E
Article type
Communication
Submitted
25 Sep 2014
Accepted
02 Oct 2014
First published
03 Oct 2014

RSC Adv., 2014,4, 50828-50831

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Renal-specific delivery of prednisolone-folate conjugates for renal ischemia/reperfusion injury

Q. Zhang, Y. Fu, R. Liu, T. Gong, X. Sun and Z. Zhang, RSC Adv., 2014, 4, 50828 DOI: 10.1039/C4RA11160E

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