Issue 109, 2014
From the journal:

RSC Advances

Reactions of β-diketone compounds with nitriles catalyzed by Lewis acids: a simple approach to β-enaminone synthesis†

Xu Cheng,a   Shuchen Pei,a   Chenchen Xue,a   Kaifei Cao,b   Li Haia  and  Yong Wu*a  

* Corresponding authors

a Key Laboratory of Drug Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, West China Hospital, Sichuan University, No. 37, GuoXue Road, Chengdu 610041, P. R. China
E-mail: wyong@scu.edu.cn
Fax: +86 2885503666

b Clinical Medicine School, Chengdu University of Traditional Chinese Medicine, No. 37 12-bridge Road, Chengdu, P. R. China

Abstract

Aluminium chloride selectively promoted the nucleophilic attack of β-diketone compounds with nitriles to give enaminones. Moreover a plausible mechanism for this transformation was given.

Graphical abstract: Reactions of β-diketone compounds with nitriles catalyzed by Lewis acids: a simple approach to β-enaminone synthesis

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Article information

DOI
https://doi.org/10.1039/C4RA10879E
Article type
Paper
Submitted
21 Sep 2014
Accepted
20 Nov 2014
First published
20 Nov 2014

RSC Adv., 2014,4, 63897-63900

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Reactions of β-diketone compounds with nitriles catalyzed by Lewis acids: a simple approach to β-enaminone synthesis

X. Cheng, S. Pei, C. Xue, K. Cao, L. Hai and Y. Wu, RSC Adv., 2014, 4, 63897 DOI: 10.1039/C4RA10879E

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