Stereospecific synthetic approach towards Tamiflu using the Ramberg–Backlund reaction from cysteine hydrochloride

Abstract

The stereospecific formal synthesis of Tamiflu from L-cysteine hydrochloride as the chiral source is described. The notable feature of the present strategy is the Ramberg–Backlund reaction and Sharpless–Reich protocol as the key chemical transformations to access the cyclohexene skeleton of Tamiflu.