The total synthesis of alkaloid cruciferane is performed in three steps with an overall yield of 60.3%. The key step involves the in situ epoxidation of indole followed by tandem Cyclization via epoxide ring opening to furnish the 3-hydroxypyrroloindoline skeleton. This methodology gave a step economical and protecting group free total synthesis of cruciferane.
S. K. Ghosh and R. Nagarajan, RSC Adv., 2014, 4, 63147 DOI: 10.1039/C4RA10309B
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