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Issue 99, 2014
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A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging

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Abstract

Based on a semi-cyanine fluorophore, a selective turn-on fluorescent probe semi-CyHP for the detection of nitroreductase (NTR) and hypoxia was designed and synthesized. It can be activated by NTR and to restore the pull–push electronic systems of semi-CyHF, which strongly fluoresces at 556 nm. Besides, the investigation of the hypoxic tumor cell imaging with semi-CyHP was significant with minimal endogenous interference.

Graphical abstract: A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging

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Publication details

The article was received on 09 Sep 2014, accepted on 22 Oct 2014 and first published on 24 Oct 2014


Article type: Communication
DOI: 10.1039/C4RA10044A
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Citation: RSC Adv., 2014,4, 56207-56210

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    A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging

    J. Yuan, Y. Xu, N. Zhou, R. Wang, X. Qian and Y. Xu, RSC Adv., 2014, 4, 56207
    DOI: 10.1039/C4RA10044A

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