Issue 101, 2014

Synthesis of N-alkyl pyrroles via decarboxylation/dehydration in neutral ionic liquid under catalyst-free conditions

Abstract

A general route to N-alkyl pyrroles by reacting aromatic, heteroaromatic or aliphatic aldehydes with 4-hydroxyproline in ionic liquid under neutral condition was developed. The ionic liquid can be readily recovered and reused for up to 5 reaction cycles without any effect on the yield of the product formed. The utility of the protocol for the one-pot synthesis of 9H-benzo[e]pyrrolo[2,1-b][1,3]oxazines is also presented.

Graphical abstract: Synthesis of N-alkyl pyrroles via decarboxylation/dehydration in neutral ionic liquid under catalyst-free conditions

Supplementary files

Article information

Article type
Paper
Submitted
04 Sep 2014
Accepted
28 Oct 2014
First published
29 Oct 2014

RSC Adv., 2014,4, 57587-57590

Author version available

Synthesis of N-alkyl pyrroles via decarboxylation/dehydration in neutral ionic liquid under catalyst-free conditions

V. D. Yadav, S. U. Dighe and S. Batra, RSC Adv., 2014, 4, 57587 DOI: 10.1039/C4RA09797A

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