Copper-catalyzed enantioselective propargylic substitution of propargylic acetates with enamines†
Abstract
With the use of chiral tridentate P,N,N ligand, copper-catalyzed enantioselective propargylic substitution of propargylic acetates with enamines has been achieved, giving the corresponding propargylic ketones in high yields and with excellent enantioselectivities.