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Issue 94, 2014
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Drug-like chelating agents: a potential lead for Alzheimer's disease

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Abstract

Recent evidence has indicated that dyshomeostasis of biometals (Fe, Cu, Zn) in the brain might contributes to the pathogenesis of Alzheimer's disease (AD). Experiments have also found that the level of metal ions in AD patients was 3–7 fold higher than that of healthy individuals. Many drug-like chelating agents were found to be able to reverse Aβ aggregation, dissolve amyloid plaques and delay the AD-related cognitive impairment. This review systematically discusses the drug-like chelating agents for AD as well as their potential applications in the future.

Graphical abstract: Drug-like chelating agents: a potential lead for Alzheimer's disease

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Publication details

The article was received on 25 Aug 2014, accepted on 09 Oct 2014 and first published on 09 Oct 2014


Article type: Review Article
DOI: 10.1039/C4RA09193K
Citation: RSC Adv., 2014,4, 52088-52099

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    Drug-like chelating agents: a potential lead for Alzheimer's disease

    W. Huang, W. Wei and Z. Shen, RSC Adv., 2014, 4, 52088
    DOI: 10.1039/C4RA09193K

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