Cu(N-heterocyclic carbene)chloride: an efficient catalyst for multicomponent click reaction for the synthesis of 1,2,3-triazoles in water at room temperature

Abstract

A novel water soluble copper(N-heterocyclic carbene)chloride [Cu(NHC)Cl] complex of vitamin B₁ was synthesized and characterized by EDX, FT-IR and NMR spectroscopy. It was employed for three component click reaction of benzyl chlorides 1a–e, alkynes 2a–c and sodium azide 3 in water at room temperature. All the synthesized compounds 4a–o were characterized by elemental analysis, IR, and ¹HNMR spectroscopy. The catalyst was easy to prepare, very versatile, reusable and was found to be highly active at low catalyst loading for a variety of substrates with a varied nature of substituents.