Issue 88, 2014
From the journal:

RSC Advances

Fluorescence enhancement, cellular imaging and biological investigation of chiral pyrrolidinol modified naphthalimide derivatives†

Ke-Rang Wang,*ab   Feng Qian,a   Rui-Xue Rong,c   Zhi-Ran Cao,c   Xiao-Man Wangc  and  Xiao-Liu Li*ab  

* Corresponding authors

a Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China
E-mail: kerangwang@hbu.edu.cn, lixl@hbu.cn
Tel: +86-312-5971116

b Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Baoding 071002, China

c Department of Immunology, School of Basic Medical Science, Hebei University, Baoding, P. R. China

Abstract

Novel chiral pyrrolidinols modified naphthalimide derivatives NI1–4 were synthesized, which showed potent cytotoxic activities against Hela, MCF-7, SGC-7901 and A549 cells. The compounds exhibited strong fluorescence enhancement on binding to Ct-DNA and very good fluorescence imaging with A549 cells, providing a potent application of naphthalimide derivatives in developing novel dual therapeutic and imaging agents.

Graphical abstract: Fluorescence enhancement, cellular imaging and biological investigation of chiral pyrrolidinol modified naphthalimide derivatives

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Article information

DOI
https://doi.org/10.1039/C4RA08372E
Article type
Communication
Submitted
08 Aug 2014
Accepted
22 Sep 2014
First published
22 Sep 2014

RSC Adv., 2014,4, 47605-47608

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Fluorescence enhancement, cellular imaging and biological investigation of chiral pyrrolidinol modified naphthalimide derivatives

K. Wang, F. Qian, R. Rong, Z. Cao, X. Wang and X. Li, RSC Adv., 2014, 4, 47605 DOI: 10.1039/C4RA08372E

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