A simple protocol for the synthesis of a ganglioside Hp-s1 (1) starting from commercially available phytosphingosine, sialic acid, and D-glucose is described. This synthesis involved a glycosylation reaction of a phytosphingosine derived acceptor with a highly active benzyl protected glucosyl donor, a second glycosylation of a glucosyl acceptor with a sialyl donor followed by Staudinger reaction, amidation, and global deprotection as key steps.
W. Chen, R. C. Sawant, S. Yang, Y. Liao, J. Liao, S. S. Badsara and S. Luo, RSC Adv., 2014, 4, 47752 DOI: 10.1039/C4RA08272A
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