Electrogenerated base-promoted synthesis of 5-aryl-5,6-dihydro-2H-pyrano[2,3-d]pyrimidine-2,4,7-triones by multicomponent assembly of barbituric acid, aldehydes and Meldrum's acid at room temperature

Abstract

An electrochemical strategy for the synthesis of pyrano[2,3-d]pyrimidine-2,4,7-triones is described, using an electrogenerated base of the anion of barbituric acid in a one-pot, three component condensation of an aromatic aldehyde, Meldrum's acid and barbituric acid in ethanol in an undivided cell and in the presence of sodium bromide as an electrolyte at room temperature. This protocol has the advantages of high yields, wide application scope and an environmentally benign procedure.