Issue 84, 2014

Copper-catalyzed tandem N-arylation/condensation: synthesis of quinazolin-4(3H)-ones from 2-halobenzonitriles and amides

Abstract

A novel, straightforward and practical copper-catalyzed domino protocol for synthesis of quinazolin-4(3H)-one derivatives from commercially available 2-halobenzonitriles and amides was successfully developed.

Graphical abstract: Copper-catalyzed tandem N-arylation/condensation: synthesis of quinazolin-4(3H)-ones from 2-halobenzonitriles and amides

Supplementary files

Article information

Article type
Communication
Submitted
02 Aug 2014
Accepted
08 Sep 2014
First published
08 Sep 2014

RSC Adv., 2014,4, 44811-44814

Author version available

Copper-catalyzed tandem N-arylation/condensation: synthesis of quinazolin-4(3H)-ones from 2-halobenzonitriles and amides

H. Chai, J. Li, L. Yang, H. Lu, Z. Qi and D. Shi, RSC Adv., 2014, 4, 44811 DOI: 10.1039/C4RA08031A

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