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Issue 74, 2014
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Transition metal-catalyzed redox isomerization of codeine and morphine in water

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Abstract

A water-soluble rhodium complex formed from commercially available [Rh(COD)(CH3CN)2]BF4 and 1,3,5-triaza-7-phosphaadamantane (PTA) catalyzes the isomerization of both codeine and morphine into hydrocodone and hydromorphone with very high efficiency. The reaction is performed in water, allowing isolation of the final products by simple filtration, which results in very high isolated yields. The reactions can be easily scaled up to 100 g.

Graphical abstract: Transition metal-catalyzed redox isomerization of codeine and morphine in water

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Supplementary files

Article information


Submitted
28 Jul 2014
Accepted
06 Aug 2014
First published
06 Aug 2014

RSC Adv., 2014,4, 39519-39522
Article type
Paper
Author version available

Transition metal-catalyzed redox isomerization of codeine and morphine in water

A. B. Gómez, P. Holmberg, Jan-E. Bäckvall and B. Martín-Matute, RSC Adv., 2014, 4, 39519
DOI: 10.1039/C4RA07735K

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