Issue 72, 2014
From the journal:

RSC Advances

Cu–benzotriazole-catalyzed electrophilic cyclization of N-arylimines: a methodical tandem approach to O-protected-4hydroxyquinazolines-†

Satyanarayana Battula,ab   Ram A. Vishwakarma*ab  and  Qazi Naveed Ahmed*ab  

* Corresponding authors

a Medicinal Chemistry Division, Indian Institute of Integrative Medicine (IIIM), Jammu, India
E-mail: ram@iiim.ac.in, naqazi@iiim.ac.in

b Academy of Scientific and Innovative Research (AcSIR), Central Road Research Institute, New Delhi – 110 025, India

Abstract

A remarkably efficient approach to O-protected-4-hydroxyquinazolines has been developed via the copper–benzotriazole (Cu–BtH)-catalyzed intramolecular electrophilic cyclization of N-arylimines, achieved through the reaction of 2-aminobenzonitriles and various aldehydes.

Graphical abstract: Cu–benzotriazole-catalyzed electrophilic cyclization of N-arylimines: a methodical tandem approach to O-protected-4hydroxyquinazolines-

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Article information

DOI
https://doi.org/10.1039/C4RA07377K
Article type
Communication
Submitted
15 Jul 2014
Accepted
05 Aug 2014
First published
05 Aug 2014

RSC Adv., 2014,4, 38375-38378

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Cu–benzotriazole-catalyzed electrophilic cyclization of N-arylimines: a methodical tandem approach to O-protected-4hydroxyquinazolines-

S. Battula, R. A. Vishwakarma and Q. N. Ahmed, RSC Adv., 2014, 4, 38375 DOI: 10.1039/C4RA07377K

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