Cu–benzotriazole-catalyzed electrophilic cyclization of N-arylimines: a methodical tandem approach to O-protected-4hydroxyquinazolines-†
Abstract
A remarkably efficient approach to O-protected-4-hydroxyquinazolines has been developed via the copper–benzotriazole (Cu–BtH)-catalyzed intramolecular electrophilic cyclization of N-arylimines, achieved through the reaction of 2-aminobenzonitriles and various aldehydes.