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Issue 74, 2014
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Inertia-activated cell sorting of immune-specifically labeled cells in a microfluidic device

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Abstract

This paper demonstrates an inertia-activated cell sorting method to separate cells based on their surface protein expression by using inertial microfluidics. Target cells are immune-specifically reacted with antibody-coated microbeads and then separated from nontarget cells. As a proof of concept, separation of MCF-7 breast cancer cells from U937 lymphoma cells was achieved with 97.6% target cell recovery rate, 95% nontarget cell rejection ratio, 73.8% purity, and an enrichment ratio of 93 at a total flow rate of 8.75 mL h−1 without using any external forces.

Graphical abstract: Inertia-activated cell sorting of immune-specifically labeled cells in a microfluidic device

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Publication details

The article was received on 27 Jun 2014, accepted on 15 Aug 2014 and first published on 15 Aug 2014


Article type: Communication
DOI: 10.1039/C4RA06296E
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Citation: RSC Adv., 2014,4, 39140-39144
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    Inertia-activated cell sorting of immune-specifically labeled cells in a microfluidic device

    J. H. Shin, M. G. Lee, S. Choi and J. Park, RSC Adv., 2014, 4, 39140
    DOI: 10.1039/C4RA06296E

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