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Issue 77, 2014
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Recent developments in one-pot tandem oxidation process coupling reactions

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Abstract

The tandem oxidation process (TOP) constitutes a novel approach to synthetic organic chemistry. This procedure involves the oxidation of the alcohol to the aldehyde which is trapped in situ by a nucleophile leading to a variety of synthetically useful compounds. In recent times, many research groups have focused their attention on developing new approaches to the one-pot coupling process. In this review, we highlight the latest additions, over the past nine years, to the TOP realm such as the use of novel oxidants, innovative catalysts and alternate reaction conditions. In addition, the introduction of TOP to multicomponent reactions and total syntheses will also be discussed.

Graphical abstract: Recent developments in one-pot tandem oxidation process coupling reactions

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Article information


Submitted
24 Jun 2014
Accepted
19 Aug 2014
First published
19 Aug 2014

RSC Adv., 2014,4, 40720-40739
Article type
Review Article
Author version available

Recent developments in one-pot tandem oxidation process coupling reactions

V. Jeena and R. S. Robinson, RSC Adv., 2014, 4, 40720
DOI: 10.1039/C4RA06169A

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