The formal and total syntheses of the macrolide antibiotic (−)-A26771B have been developed wherein the stereochemistries at its C-5 and C-15 centres were installed using the lipase-catalyzed acylation of suitable MeCH(OH) and allylic secondary carbinol centres. A lipase-catalyzed chemoselective and hazard-free acrylation protocol, and a ring-closing metathesis reaction were used to construct the macrocyclic skeleton.
S. Chatterjee, A. Sharma and S. Chattopadhyay, RSC Adv., 2014, 4, 42697 DOI: 10.1039/C4RA05399K
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