Issue 72, 2014
From the journal:

RSC Advances

Synthesis of β-enaminodicarbonyl derivatives in the titanium(iv) chloride-promoted reactions of β-dicarbonyl compounds with nitriles†

Shuchen Pei,a   Chenchen Xue,a   Li Haia  and  Yong Wu*a  

* Corresponding authors

a Key Laboratory of Drug Targeting of Education Ministry, West China School of Pharmacy, West China Hospital, Sichuan University, No. 37, GuoXue Road, Chengdu 610041, P.R. China
E-mail: wyong@scu.edu.cn
Fax: +862885503666

Abstract

Titanium(IV) chloride selectively promoted the nucleophilic attack of ethyl acetoacetate with nitriles to give enaminoketoesters, which were valuable intermediates for the syntheses of 2,3,4-substituted heterocyclics. Moreover a plausible mechanism for this transformation was given.

Graphical abstract: Synthesis of β-enaminodicarbonyl derivatives in the titanium(iv) chloride-promoted reactions of β-dicarbonyl compounds with nitriles

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Article information

DOI
https://doi.org/10.1039/C4RA05100A
Article type
Paper
Submitted
29 May 2014
Accepted
15 Aug 2014
First published
18 Aug 2014

RSC Adv., 2014,4, 38055-38058

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Synthesis of β-enaminodicarbonyl derivatives in the titanium(IV) chloride-promoted reactions of β-dicarbonyl compounds with nitriles

S. Pei, C. Xue, L. Hai and Y. Wu, RSC Adv., 2014, 4, 38055 DOI: 10.1039/C4RA05100A

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