Trienediynes on a 1,3,5-trisubstituted benzene template: a new approach for enhancement of reactivity†
Abstract
The synthesis of trienediynes based on a 1,3,5-trisubstituted benzene template is described. The presence of three adjacent enediyne moieties in the dendritic core exerted a cooperative effect to bring down the onset temperature for Bergman cyclization leading to increased DNA cleavage in a shorter time.