Issue 60, 2014
From the journal:

RSC Advances

Ruthenium-catalyzed direct C-3 oxidative olefination of imidazo[1,2-a]pyridines†

Haiying Zhan,a   Limin Zhao,*a   Naiying Li,a   Longbin Chen,a   Jingyun Liu,a   Jinqiang Liaoa  and  Hua Cao*a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, P. R. China
E-mail: caohua@gdpu.edu.cn
Fax: +86 760 88207939

Abstract

A highly regioselective oxidative olefination of imidazo[1,2-a]pyridines with acrylates has been accomplished in the presence of ruthenium catalysts to form only the C-3 coupling products. The oxidative olefination has provided step economical access to diversely substituted imidazo[1,2-a]pyridine derivatives with excellent C-3 regioselectivity and E-stereoselectivity.

Graphical abstract: Ruthenium-catalyzed direct C-3 oxidative olefination of imidazo[1,2-a]pyridines

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Article information

DOI
https://doi.org/10.1039/C4RA04669B
Article type
Communication
Submitted
29 May 2014
Accepted
15 Jul 2014
First published
16 Jul 2014

RSC Adv., 2014,4, 32013-32016

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Ruthenium-catalyzed direct C-3 oxidative olefination of imidazo[1,2-a]pyridines

H. Zhan, L. Zhao, N. Li, L. Chen, J. Liu, J. Liao and H. Cao, RSC Adv., 2014, 4, 32013 DOI: 10.1039/C4RA04669B

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