Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 61, 2014
Previous Article Next Article

Efficient and scalable total synthesis of calcitroic acid and its 13C-labeled derivative

Author affiliations

Abstract

Calcitroic acid, the deactivated form of the physiological active vitamin D3 metabolite calcitrol, and its 13C labeled derivative has been synthesized starting from the commercially available Inhoffen-Lythgoe diol in 11 steps with an overall yield of 21%. The key steps in the synthesis were the formation of the C1-homologated nitrile with KCN and K13CN as well as the Horner–Wittig reaction with the ring A phosphine oxide reagent.

Graphical abstract: Efficient and scalable total synthesis of calcitroic acid and its 13C-labeled derivative

Back to tab navigation

Supplementary files

Article information


Submitted
09 May 2014
Accepted
10 Jul 2014
First published
14 Jul 2014

RSC Adv., 2014,4, 32327-32334
Article type
Paper
Author version available

Efficient and scalable total synthesis of calcitroic acid and its 13C-labeled derivative

D. Meyer, L. Rentsch and R. Marti, RSC Adv., 2014, 4, 32327
DOI: 10.1039/C4RA04322G

Social activity

Search articles by author

Spotlight

Advertisements