Issue 62, 2014

One-pot route to β-adrenergic blockers via enantioselective organocatalysed epoxidation of terminal alkenes as a key step

Abstract

A convenient and environmentally attractive one-pot two-step process for the synthesis of β-adrenergic blockers via Shi's organocatalytic epoxidation of terminal alkenes and subsequent aminolysis reaction of epoxides with isopropylamine under mild reaction conditions has been developed.

Graphical abstract: One-pot route to β-adrenergic blockers via enantioselective organocatalysed epoxidation of terminal alkenes as a key step

Supplementary files

Article information

Article type
Paper
Submitted
01 May 2014
Accepted
10 Jul 2014
First published
16 Jul 2014
This article is Open Access
Creative Commons BY license

RSC Adv., 2014,4, 32796-32801

One-pot route to β-adrenergic blockers via enantioselective organocatalysed epoxidation of terminal alkenes as a key step

F. E. Held, S. Wei, K. Eder and S. B. Tsogoeva, RSC Adv., 2014, 4, 32796 DOI: 10.1039/C4RA04011B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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