The human copper metallochaperone (CCS) for Cu,Zn-superoxide dismutase (SOD1) has a similar Zn(II) site as that in SOD1. Dimeric CCS converts to a monomer in the reduced Zn(II)-free form that weakens the interaction with SOD1. This form of CCS may be fibrillogenic and disease causing, as is the case for demetallated and reduced monomeric SOD1.
S. Allen and C. Dennison, RSC Adv., 2014, 4, 22542 DOI: 10.1039/C4RA03806A
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