Fluorogenic sensing of H2S in blood and living cells via reduction of aromatic dialkylamino N-oxide

Zhisheng Wu; Yongliang Feng; Bin Geng; Junyi Liu; Xinjing Tang

doi:10.1039/C4RA03677H

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Fluorogenic sensing of H₂S in blood and living cells via reduction of aromatic dialkylamino N-oxide†

Zhisheng Wu,^a Yongliang Feng,^b Bin Geng,^b Junyi Liu^a and Xinjing Tang*^a

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* Corresponding authors

^a State Key Laboratory of Natural and Biomimetic Drugs, the School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
E-mail: xinjingt@bjmu.edu.cn
Fax: +8610-82805635

^b Department of Physiology and Pathophysiology, the School of Basic Medical Science, Peking University, Beijing 100191, China

Abstract

A fluorescent chemodosimeter, N-oxide of 7-diethylamino-4-methylcoumarin, was developed for H₂S detection based on a new water soluble aromatic dialkylamine N-oxide group and their selectivity and sensitivity for fluorescent detection of H₂S were evaluated in aqueous solution and blood media. Fluorescence sensing of H₂S was also achieved in MCF-7 cells.

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Article information

DOI: https://doi.org/10.1039/C4RA03677H
Article type: Communication
Submitted: 23 Apr 2014
Accepted: 29 Jun 2014
First published: 30 Jun 2014

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RSC Adv., 2014,4, 30398-30401

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Fluorogenic sensing of H₂S in blood and living cells via reduction of aromatic dialkylamino N-oxide

Z. Wu, Y. Feng, B. Geng, J. Liu and X. Tang, RSC Adv., 2014, 4, 30398 DOI: 10.1039/C4RA03677H

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