Issue 53, 2014
From the journal:

RSC Advances

Bis(oxazoline)-copper catalyzed enantioselective hydrophosphonylation of aldehydes†

Tao Denga  and  Chun Cai*a  

* Corresponding authors

a Chemical Engineering College, Nanjing University of Science &Technology, Nanjing, Jiangsu 210094, P. R. China
E-mail: c.cai@mail.njust.edu.cn

Abstract

A highly enantioselective copper-catalyzed hydrophosphonylation of aldehydes in the presence of bis(oxazoline) ligand is presented. The reaction proceeded smoothly under mild conditions. The resulting α-hydroxyphosphonates were obtained with high yields as well as enantioselectivities (up to 98% ee).

Graphical abstract: Bis(oxazoline)-copper catalyzed enantioselective hydrophosphonylation of aldehydes

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Article information

DOI
https://doi.org/10.1039/C4RA03269A
Article type
Communication
Submitted
11 Apr 2014
Accepted
09 Jun 2014
First published
30 Jun 2014

RSC Adv., 2014,4, 27853-27856

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Bis(oxazoline)-copper catalyzed enantioselective hydrophosphonylation of aldehydes

T. Deng and C. Cai, RSC Adv., 2014, 4, 27853 DOI: 10.1039/C4RA03269A

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