Drug–surfactant interaction: thermo-acoustic investigation of sodium dodecyl sulfate and antimicrobial drug (levofloxacin) for potential pharmaceutical application

Abstract

In the present study, the advantages of surfactant micelles as drug delivery vehicles are taken into consideration, and the impact of the potential antimicrobial drug (levofloxacin) on the micellar system of anionic surfactant (SDS) has been studied. It would therefore be interesting to evaluate the region of micelle formation in order to design a system that could prove valuable in pharmaceutical formulations. In this context, conductance study, critical micelle concentration (CMC), and standard thermodynamic parameters of micellization, namely, ΔH^o_m, ΔG^o_m and ΔS^o_m, have been evaluated at four different temperatures (298.15 to 313.15) K. Molar volume and compressibility measurements have also been carried out to evaluate the apparent molar volume and apparent molar adiabatic compression of drug–surfactant complex and discussed in terms of the solute–solute and solute–solvent interactions. In addition, spectroscopic analysis (FTIR and ¹H-NMR) confirmed the presence of intermolecular interaction between levofloxacin–SDS moiety within the studied concentration. In conclusion, this study provides an indication to assess and develop surfactant immobilized levofloxacin for better biological activity.