Pd-catalyzed dehydrogenative cross-coupling of pyridine-N-oxides with uracils†
Abstract
A highly efficient protocol for the regioselective dehydrogenative cross-coupling of pyridine-N-oxides with N,N-dialkyl uracils via 2-fold C–H activation has been developed. The resultant uracil substituted pyridine-N-oxide structural motifs is readily deoxygenated, making the present procedure a highly attractive route for the synthesis of 5-pyridine substituted uracils.