Issue 28, 2014
From the journal:

RSC Advances

A protecting group free and scalable approach towards total synthesis of (−)-venlafaxine†

Subhash P. Chavan,*a   Kailash P. Pawara  and  Sumanta Garaia  

* Corresponding authors

a Division of Organic Chemistry, CSIR-NCL (National Chemical Laboratory), Pune-411008, India
E-mail: sp.chavan@ncl.res.in
Fax: +91-20-5892629

Abstract

A protecting group free asymmetric total synthesis of (−)-venlafaxine is reported. The strategy employs Sharpless epoxidation and regio-selective epoxide ring opening by an in situ generated Gilman reagent as key steps. This paper reports a 53% overall yield in 6 steps for total synthesis of (−)-venlafaxine.

Graphical abstract: A protecting group free and scalable approach towards total synthesis of (−)-venlafaxine

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Article information

DOI
https://doi.org/10.1039/C4RA00840E
Article type
Communication
Submitted
30 Jan 2014
Accepted
11 Mar 2014
First published
11 Mar 2014

RSC Adv., 2014,4, 14468-14470

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A protecting group free and scalable approach towards total synthesis of (−)-venlafaxine

S. P. Chavan, K. P. Pawar and S. Garai, RSC Adv., 2014, 4, 14468 DOI: 10.1039/C4RA00840E

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