Issue 21, 2014

Enantioselective synthesis of N-allylindoles via palladium-catalyzed allylic amination/oxidation of indolines

Abstract

A highly efficient synthesis of N-allylindoles was realized via palladium-catalyzed asymmetric allylic amination/oxidation sequential reaction of indolines. The N-alkylated indole derivatives were obtained with up to 91% yield and 97% ee.

Graphical abstract: Enantioselective synthesis of N-allylindoles via palladium-catalyzed allylic amination/oxidation of indolines

Supplementary files

Article information

Article type
Communication
Submitted
06 Jan 2014
Accepted
05 Feb 2014
First published
05 Feb 2014

RSC Adv., 2014,4, 10875-10878

Enantioselective synthesis of N-allylindoles via palladium-catalyzed allylic amination/oxidation of indolines

Q. Zhao, C. Zhuo and S. You, RSC Adv., 2014, 4, 10875 DOI: 10.1039/C4RA00701H

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