Issue 27, 2014
From the journal:

RSC Advances

The development of chitosan based microcapsules as delivery vehicles for orally administered daunorubicin

P.-L. Lam,a   K. K.-H. Lee,b   Y.-W. Ho,c   R. S.-M. Wong,b   S.-W. Tong,b   C.-H. Cheng,a   K.-H. Lam,a   J. C.-O. Tang,a   Z.-X. Bian,d   R. Gambari,*e   S. H.-L. Kok*b  and  C.-H. Chui*ad  

* Corresponding authors

a State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, P.R. China

b MOE Key Laboratory for Regenerative Medicine, School of Biomedical Sciences, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, P.R. China
E-mail: stanton@cuhk.edu.hk
Fax: +852-2603 5139
Tel: +852-3943 6785

c Private Practice, Shop 4, G/F., Phase I, Allway Gardens, Tsuen Wan, Hong Kong, P.R. China

d Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, P.R. China
E-mail: chchui@hkbu.edu.hk
Fax: +852-2637 5396
Tel: +852-2632 1500

e BioPharmaNet, Department of Biochemistry and Molecular Biology, The University of Ferrara, Ferrara, Italy
E-mail: gam@unife.it
Fax: +39-532-202723
Tel: +39-532-974443

Abstract

This study reports the use of chitosan microcapsules for daunorubicin delivery via an oral route. The potential oral delivery of the daunorubicin/chitosan microcapsules was examined using an in vivo athymic nude mice xenograft model with Non-Hodgkin's lymphoma cells. Microencapsulated daunorubicin could be administered orally with tumour growth inhibition activity.

Graphical abstract: The development of chitosan based microcapsules as delivery vehicles for orally administered daunorubicin

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Article information

DOI
https://doi.org/10.1039/C4RA00195H
Article type
Paper
Submitted
09 Jan 2014
Accepted
28 Jan 2014
First published
28 Jan 2014

RSC Adv., 2014,4, 14109-14114

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The development of chitosan based microcapsules as delivery vehicles for orally administered daunorubicin

P.-L. Lam, K. K.-H. Lee, Y.-W. Ho, R. S.-M. Wong, S.-W. Tong, C.-H. Cheng, K.-H. Lam, J. C.-O. Tang, Z.-X. Bian, R. Gambari, S. H.-L. Kok and C.-H. Chui, RSC Adv., 2014, 4, 14109 DOI: 10.1039/C4RA00195H

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