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Issue 31, 2014
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Biologically active isoquinoline alkaloids with drug-like properties from the genus Corydalis

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Abstract

The genus Corydalis (Papaveraceae), comprising more than 400 species in Eurasia and North America, is a rich source of isoquinoline alkaloids with various biological properties including acetylcholinesterase inhibitory effects, anti-proliferative activities, antiviral activities and antiplasmodial activities. Traditionally, some Corydalis species have long been used to treat gastric and duodenal ulcers, dysmenorrhoea, rheumatism and cardiac arrhythmia disease and this traditional background so far has proven pharmacological activities resulting in isolation of more than 100 isoquinoline alkaloids from this genus. This overview aims to inform medicinal chemists of the good drug-like properties and versatile biological activities of Corydalis alkaloids to stimulate further medicinal chemistry research. Mechanisms of action and structure–activity relationship of Corydalis alkaloids are also included.

Graphical abstract: Biologically active isoquinoline alkaloids with drug-like properties from the genus Corydalis

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Publication details

The article was received on 24 Dec 2013, accepted on 10 Mar 2014 and first published on 12 Mar 2014


Article type: Review Article
DOI: 10.1039/C3RA47944G
RSC Adv., 2014,4, 15900-15913

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    Biologically active isoquinoline alkaloids with drug-like properties from the genus Corydalis

    M. Iranshahy, R. J. Quinn and M. Iranshahi, RSC Adv., 2014, 4, 15900
    DOI: 10.1039/C3RA47944G

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