Issue 26, 2014

Oligonucleotides with consecutive alkylated phosphate units: aggregation characteristics and drug transport into living cells

Abstract

We prepared DNA amphiphiles with modified phosphate units, and characterized their properties of aggregate formation. The oligodeoxynucleotides with five consecutive hydrophobic phosphate groups aggregated to encapsulate hydrophobic nile red dye, and the resulting aggregates efficiently delivered the hydrophobic nile red as a virtual drug into living cells.

Graphical abstract: Oligonucleotides with consecutive alkylated phosphate units: aggregation characteristics and drug transport into living cells

Supplementary files

Article information

Article type
Communication
Submitted
16 Dec 2013
Accepted
19 Feb 2014
First published
03 Mar 2014

RSC Adv., 2014,4, 13367-13370

Oligonucleotides with consecutive alkylated phosphate units: aggregation characteristics and drug transport into living cells

K. Tanabe, Y. Ando, D. Hara, T. Ito and S. Nishimoto, RSC Adv., 2014, 4, 13367 DOI: 10.1039/C3RA47662F

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