Issue 14, 2014

Condensation dynamics of l-proline and l-hydroxyproline in solution

Abstract

We employ high-performance liquid chromatography with evaporative light scattering and mass spectrometric detection (HPLC/ELSD and LC/MS) to monitor the dynamic behavior of L-Pro, L-Hyp, and L-Pro–L-Hyp in 70% aqueous methanol. The individual amino acid solutions show evidence of oscillatory oligomerization. In the binary solution, the behavior is controlled by the dynamics of L-Pro oligomerization. A simple model involving oligomerization, formation of catalytic oligomer aggregates and cross-catalysis provides qualitative insight into the process.

Graphical abstract: Condensation dynamics of l-proline and l-hydroxyproline in solution

Article information

Article type
Paper
Submitted
21 Nov 2013
Accepted
04 Jan 2014
First published
09 Jan 2014

RSC Adv., 2014,4, 7330-7339

Condensation dynamics of L-proline and L-hydroxyproline in solution

M. Sajewicz, M. Dolnik, T. Kowalska and I. R. Epstein, RSC Adv., 2014, 4, 7330 DOI: 10.1039/C3RA46921B

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