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Issue 23, 2014
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A novel synthesis of tetra and pentacyclic quinolinopyran tethered pyrazole/coumarin scaffolds via a solid state melt reaction

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Abstract

A new protocol has been developed for the efficient synthesis of structurally diverse tetra- and pentacyclic quinolinopyran tethered pyrazole/coumarin architectures via a domino Knoevenagel intramolecular hetero-Diels–Alder (IMHDA) strategy using a solid state melt reaction (SSMR) in a highly diastereo and regioselective fashion. Gratifyingly, these heterocyclic frameworks were synthesized under solvent and catalyst free conditions, without the aid of a work-up and column chromatography purification. The generality and functional tolerance of this convergent and environmentally benign method is very attractive.

Graphical abstract: A novel synthesis of tetra and pentacyclic quinolinopyran tethered pyrazole/coumarin scaffolds via a solid state melt reaction

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Supplementary files

Article information


Submitted
21 Nov 2013
Accepted
06 Jan 2014
First published
09 Jan 2014

RSC Adv., 2014,4, 11723-11731
Article type
Paper

A novel synthesis of tetra and pentacyclic quinolinopyran tethered pyrazole/coumarin scaffolds via a solid state melt reaction

M. Bakthadoss and D. Kannan, RSC Adv., 2014, 4, 11723
DOI: 10.1039/C3RA46894A

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