Issue 8, 2014
From the journal:

RSC Advances

Benzoyl methyl phosphates as efficient reagents in the one-pot tandem approach for the synthesis of 2-phenylbenzimidazoles in water†

Hidemasa Hikawa,*a   Maki Imani,a   Hideharu Suzuki,a   Yuusaku Yokoyamaa  and  Isao Azumaya*a  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan
E-mail: hidemasa.hikawa@phar.toho-u.ac.jp, isao.azumaya@phar.toho-u.ac.jp

Abstract

A novel and efficient method for the environmentally benign, catalyst- and auxiliary-free synthesis of 2-phenylbenzimidazoles in water is developed. Benzoyl methyl phosphates play important roles as biomimetic acylating agents for the one-pot tandem approach without additional catalysts.

Graphical abstract: Benzoyl methyl phosphates as efficient reagents in the one-pot tandem approach for the synthesis of 2-phenylbenzimidazoles in water

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Article information

DOI
https://doi.org/10.1039/C3RA46749J
Article type
Paper
Submitted
09 Oct 2013
Accepted
26 Nov 2013
First published
29 Nov 2013

RSC Adv., 2014,4, 3768-3773

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Benzoyl methyl phosphates as efficient reagents in the one-pot tandem approach for the synthesis of 2-phenylbenzimidazoles in water

H. Hikawa, M. Imani, H. Suzuki, Y. Yokoyama and I. Azumaya, RSC Adv., 2014, 4, 3768 DOI: 10.1039/C3RA46749J

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