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Issue 29, 2014
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Synthesis and medicinal chemistry of selected antitubercular natural products and natural product derivatives

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Abstract

Despite advances in molecular methods for the diagnosis of tuberculosis (TB) and its resistant forms, it remains more prevalent in the world today than at any other time in human history. Of equal concern is the slow moving antitubercular drug development pipeline which calls for research efforts to be intensified and directed towards the discovery of new molecular scaffolds and/or the remodelling of some old TB drug families. In support of the latter, this review highlights synthetic methodologies and structure activity relationships (SARs) elaborated for natural products and/or natural product derivatives with promising antitubercular activity. It further attests to the enormous potential of natural products in the antitubercular drug discovery process.

Graphical abstract: Synthesis and medicinal chemistry of selected antitubercular natural products and natural product derivatives

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Publication details

The article was received on 25 Oct 2013, accepted on 10 Mar 2014 and first published on 11 Mar 2014


Article type: Review Article
DOI: 10.1039/C3RA46124F
RSC Adv., 2014,4, 15180-15215

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    Synthesis and medicinal chemistry of selected antitubercular natural products and natural product derivatives

    A. Mahajan, R. Hans, K. Chibale and V. Kumar, RSC Adv., 2014, 4, 15180
    DOI: 10.1039/C3RA46124F

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